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. 2017 Aug 21;14(4):4805–4811. doi: 10.3892/ol.2017.6778

Figure 2.

Figure 2.

miR-182 overexpression promotes cell proliferation, migration, invasion and metastasis. (A) miR-182 is successfully re-expressed in MCF-7 and MDA-MB-231 cells as confirmed by qPCR. (B and C) Growth curves of miR-182 in MCF-7 and MDA-MB-231 cells mearsured by MTT assay. (D) Effects of ectopic expression of miR-182 on the migration and invasion of MCF-7 and MDA-MB-231 cells. (E) Tumor volume of xenograft mice injected with MDA-MB-231 cells. (F) Re-expression of miR-182 increased metastasis in vivo. Representative images of the lung sections from mice injected with MDA-MB-231/miR-182 mimic showed more distant metastatic nodules in the lung than that in MDA-MB-231/miR-182 NC cells. *P<0.05, **P<0.01. miR, microRNA; qRT-PCR, quantitative real-time PCR.