Fig. 2.

Effect of BBG on 6 Hz-induced psychomotor seizure threshold in mice. BBG was administered acutely 30 min prior to the test at doses ranging from 50 to 200 mg/kg (a) or sub-chronically for seven consecutive days at doses ranging from 25 to 100 mg/kg and the test was performed 30 min after the last injection (b). VPA (positive control) was injected 15 min before the test (acute treatment) at a dose of 50 mg/kg (c) and tested to verify reliability of the method. Results are presented as median current strengths (CS₅₀ in mA with their 95% confidence limits as the error bars) required to produce psychomotor seizures in 50% of animal tested. One-way ANOVA followed by the Tukey’s post-hoc multiple comparison test was used to analyze the data received in the groups treated with BBG while effect of VPA was analyzed using Student’s t test. *p < 0.05 and ***p < 0.001 versus control group