Table 2.

Diagnostic performance of HSI, autofluorescence imaging, 2-NBDG fluorescence imaging, and proflavine fluorescence imaging using the intra-patient classification method

Cancer site	Imaging method	AUC	Accuracy	Sensitivity	Specificity
Oral cavity (n = 12)	HSI	0.95 ± 0.05	89% ± 8%	90% ± 7%	90% ± 8%
	Autofluorescence	0.82 ± 0.20	81% ± 16%	80% ± 16%	80% ± 19%
	2-NBDG	0.83 ± 0.14	79% ± 14%	79% ± 15%	79% ± 14%
	Proflavine	0.68 ± 0.18	66% ± 14%	64% ± 16%	69% ± 15%
Gland (6 thyroid, 1 parotid)	HSI	0.96 ± 0.04	91% ± 7%	91% ± 8%	93% ± 6%
	Autofluorescence	0.72 ± 0.31	67% ± 33%	80% ± 20%	71% ± 35%
	2-NBDG	0.84 ± 0.18	80% ± 17%	78% ± 19%	82% ± 16%
	Proflavine	0.80 ± 0.23	78% ± 21%	73% ± 26%	82% ± 15%
Larynx and pharynx (n = 3)	HSI	0.97 ± 0.03	94% ± 4%	95% ± 4%	90% ± 7%
	Autofluorescence	0.74 ± 0.26	74% ± 21%	74% ± 28%	79% ± 22%
	2-NBDG	0.97 ± 0.04	92% ± 7%	92% ± 8%	92% ± 5%
	Proflavine	0.79 ± 0.23	77% ± 20%	77% ± 20%	74% ± 23%
Paranasal and nasal (n = 3)	HSI	0.96 ± 0.02	90% ± 5%	90% ± 5%	90% ± 4%
	Autofluorescence	0.81 ± 0.11	76% ± 10%	79% ± 8%	72% ± 14%
	2-NBDG	0.76 ± 0.18	68% ± 19%	64% ± 20%	79% ± 7%
	Proflavine	0.80 ± 0.08	73% ± 6%	69% ± 11%	79% ± 2%