Table 3. Results of transmission disequilibrium test allowing for errors (TDTae).
| Chromosome | dbSNP | Chromosomal location | Gene | aR2 | cMinimum of corrected P value | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dominant model | Recessive model | Multiplicative model | ||||||||
| bDSB | GHLO | DSB | GHLO | DSB | GHLO | |||||
| 7 | rs3807959 | 115853100 | TES intron | 4.4081 | 4.4081 | 12.5929 | 12.5929 | 0.008324 | ||
| 7 | rs3807967 | 115863441 | TES intron | 0.1522 | 0.1522 | 0.0416597 | ||||
| 7 | rs3807986 | 116177825 | CAV1 intron | 2.0739 | 0.0471031 | |||||
| 7 | rs3801993 | 116190382 | CAV1 intron | 8.2562 | 8.2562 | 0.0378839 | ||||
| 7 | rs3801994 | 116190469 | CAV1 intron | 8.3368 | 8.3368 | 0.0366007 | ||||
| 7 | rs41735 | 116435416 | MET intron | 0.13 | 0.13 | 0.1164 | 0.1164 | 0.019151 | ||
| 7 | rs2023748 | 116436022 | MET intron | 0.1482 | 0.1482 | 0.1228 | 0.1228 | 0.034239 | ||
| 7 | rs41737 | 116436097 | MET | 0.2547 | 0.2547 | 0.0453541 | ||||
| 7 | rs2301649 | 116538634 | CAPZA2 intron | 0.3377 | 0.033912 | |||||
| 7 | rs2074025 | 116550456 | CAPZA2 intron | 0.0169 | 0.0169 | 0.016231 | ||||
| 7 | rs38861 | 116816284 | ST7 intron | 3.3527 | 3.3527 | 6.3843 | 6.3843 | 0.018479 | ||
| 7 | rs3735646 | 116915684 | 3.3 | 3.3 | 0.0439441 | |||||
| 7 | rs2024233 | 116917427 | WNT2 3′-UTR | 6.8558 | 6.8558 | 6.8744 | 6.8744 | 0.009829 | ||
| 7 | rs3779547 | 116930962 | WNT2 intron | 0.1892 | 0.1892 | 0.0491057 | ||||
| 7 | rs3779546 | 116934200 | WNT2 intron | 0.1779 | 0.1779 | 0.031462 | ||||
| 7 | rs2285544 | 116944283 | WNT2 intron | 3.698 | 3.698 | 0.023326 | ||||
| 7 | rs4148721 | 117267954 | CFTR intron | 19.973 | 19.973 | 0.0465618 | ||||
| 4 | rs3836607 | 140579303 | 0.1473 | 0.1473 | 0.0476 | 0.0476 | 0.019239 | |||
Notes.
R1 = R2 in dominant mode of inheritance; R1 = 1 in recessive mode of inheritance; R12 = R2 in multiplicative mode of inheritance.
Douglas Skol Boehnke (DSB) error model; Gordon Heath Liu Ott (GHLO) error model.
The minimum P value (corrected for multiple testing) of dominant, multiplicative, and recessive mode of inheritance.
The corrected P value is given by 1 –(1 –p)k−1 (Gordon et al., 2004).
R1 = Pr(aff | + d)/Pr(aff | + +) and R2 = Pr(aff |dd)/Pr(aff | + +) are genotypic relative risks for a di-allelic trait locus with low-risk (wild-type) allele + and high-risk (disease) allele d. If both R1 and R2 are less than 1, the genotypic relative risk value of the other allele would be calculated by R1′ = R1/R2 and R2′ = 1/R2. A few strange results are omitted from this table (e.g., R > 10,000, or R = 0).