Figure 2. Gray matter differences between corticobasal syndrome and healthy controls, and between Alzheimer disease (AD) and nonAD pathology.

(A) Regions with significantly reduced gray matter density in individuals with corticobasal syndrome relative to controls following Bonferroni correction for multiple comparisons. A wide range of regions within the frontal, parietal, and temporal lobes demonstrated reduced density in the diseased cohort. (B) Regions with significantly different gray matter density in individuals with nonAD relative to AD. In all cases, volumes were reduced in AD relative to nonAD. Observe that only one region in the left precuneus and one region in the right medial frontal gyrus are found to be statistically significant following Bonferroni correction for multiple comparisons. In both panels, hotter colors indicate increasing statistical significance.