Table 3. Risk Factor Analysis for Progression Free Survival.
| Variable | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
| Disease stage DS | ||||||
| IIA vs IA | 0.884 | 0.292 - 2.675 | 0.8274 | 1.166 | 0.342 - 3.972 | 0.8058 |
| IIIA vs IA | 1.337 | 0.465 - 3.845 | 0.2898 | 1.722 | 0.575 - 5.157 | 0.3311 |
| IIIB vs IA | 1.439 | 0.420 - 4.930 | 0.3350 | 4.219 | 0.994 - 17.902 | 0.0509 |
| Disease stage ISS | ||||||
| II vs I | 1.467 | 0.800 - 2.692 | 0.2156 | 1.41 | 0.699 - 2.845 | 0.3376 |
| III vs I | 0.742 | 0.304 - 1.808 | 0.5110 | 0.533 | 0.189 - 1.508 | 0.2358 |
| Cytogenetics/FISH | ||||||
| 3 vs 1 | 1.178 | 0.496 - 2.797 | 0.7107 | 0.997 | 0.391 - 2.44 | 0.9598 |
| 2 vs 1 | 1.750 | 0.483 - 6.254 | 0.3894 | 2.411 | 0.638 - 9.109 | 0.1943 |
| Negative vs Positive conventional skeletal survey |
0.522 | 0.253 - 1.077 | 0.0784 | 0.396 | 0.172 - 0.910 | 0.0291 |
| Gender | ||||||
| Male vs Female | 0.998 | 0.577 - 1.726 | 0.9944 | 1.088 | 0.603 - 1.963 | 0.7795 |
| Age | 1.005 | 0.977 - 1.033 | 0.7452 | 1.005 | 0.973 - 1.039 | 0.7534 |
Abbreviations: DS: Durie-Salmon stage; ISS: International staging system; FISH: fluorescence in situ hybridization; Definitions of cytogenetics: 1-poor prognosis, complex abnormalities with del 13, 17p, or t(4:14), or any of these abnormalities; 2- Intermediate prognosis, normal chromosomes, Del 13 by FISH only; 3- Good prognosis, hyperdiploidy, t(11,14).