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| Adenocarcinoma | Pancreatic endocrine tumors | Intraductal papillary mucinous tumors |
|---|---|---|
| Sporadic | ||
| K – ras | Men-1 | K-ras |
| P53 | P16 | P53 |
| P16 | P27 | P16 |
| DPC4 | Cyclin D | |
| DPC4 | ||
| Hereditary | ||
| PRSS1 | Men-1 | |
| FAMM (p16) | Von Hippel Lindau (VHL) | |
| STK11/LKB1 | Von Recklinghausen’s | |
| BRCA 2 | disease (NF-1) | |
| HNPCC | Tuberous Sclerosis | |
| Li Fraumeni Syndrome (p53) | (TSC1, TSC2) | |
