Table 3.

Odds Ratios for Hospital Mortality Based on the Time of Antibiotic Administration in Unadjusted and Adjusted Logistic Regression Models

Model	Odds Ratio for Hospital Mortality, per Elapsed Hour until Antibiotic Administration	95% CI	P Value
Unadjusted	0.89	0.86–0.91	<0.001
+ Sepsis severity strata	0.96	0.93–0.99	0.013
+ Severity of illness	1.08	1.04–1.12	<0.001
+ Demographics	1.09	1.05–1.13	<0.001
Fully adjusted model, in each subgroup
Sepsis only	1.09	1.00–1.19	0.046
Severe sepsis only	1.07	1.01–1.24	0.014
Septic shock only	1.14	1.06–1.23	0.001

Definition of abbreviation: CI = confidence interval.

Beyond the unadjusted model, each subsequent model includes an additional set of covariates, including sepsis severity strata (categorized as sepsis, severe sepsis, or septic shock), severity of illness (Laboratory and Acute Physiology Score, version 2; Emergency Severity Index; mean vital sign values; presence of altered mental status; laboratory data; need for direct intensive care unit transfer; number of vasopressors given within the first h; and number of antibiotics given within 6 h), and demographics (age; sex; code status; Comorbidity Point Score, version 2; and facility). The results of the fully adjusted model within each sepsis severity subgroup are shown at the bottom of the table.