Table 2.

Supine Lung Function

	Room Air		80% Oxygen		Two-Way RM ANOVA
	Baseline	Methacholine	Baseline	Methacholine	Room Air vs. 80% Oxygen	Baseline vs. Methacholine	Interaction
FEV1, % predicted, % decrease from baseline	83.3 ± 5.0	66.3 ± 4.7*, 18.9 ± 16.6%	83.4 ± 5.2	66.8 ± 5.5*, 19.3 ± 15.4%	n.s.	P < 0.05	n.s.
FVC, % predicted, % decrease from baseline	90.1 ± 5.0	82.4 ± 5.9, 8.5 ± 14.5%	91.4 ± 4.9	82.6 ± 5.4, 7.9 ± 15.4%	n.s.	n.s.	n.s.
FEV1/FVC, %	78.1 ± 3.1	68.4 ± 3.8†	77.0 ± 3.6	68.3 ± 3.8†	n.s.	P < 0.01	n.s.
Oxygen saturation, %	99.4 ± 1.0	98.5 ± 1.4	99.7 ± 1.0	99.7 ± 0.5	n.s.	n.s.	n.s.
Heart rate, bpm	64.5 ± 6.0	72.1 ± 16.1	64.3 ± 10.9	66.6 ± 10.7	n.s.	n.s.	n.s.
Blood pressure, systolic/diastolic, mm Hg	102/56 ± 9/10	109/63* ± 5/10	107/61 ± 13/14	108/60 ± 11/11	n.s.	Diastolic: P < 0.05	n.s.
Mean lung volume, L	3.2 ± 1.1	3.6 ± 0.9	3.2 ± 0.9	3.7 ± 1.1	n.s.	P < 0.05	n.s.

Definition of abbreviations: bpm = beats per minute; n.s. = not significant; RM ANOVA = repeated-measures analysis of variance.

Percentage predicted values were calculated on the basis of publication by Hankinson and colleagues (54).

^*P < 0.01 significant difference between baseline and after methacholine using post hoc analysis.

^†P < 0.001 significant difference between baseline and after methacholine using post hoc analysis.