Table 2.
Cell Surface Phenotype of Human and Mouse Dendritic Cells
Species | Subpopulation | Subsets | Cell Surface Marker | Residence in Lung under Steady State | Toll-Like Receptors | CCRs on Immature DCs | CCRs on Mature DCs |
---|---|---|---|---|---|---|---|
Mouse | cDC | CD11b+ DC | CD11c+, CD8α−, CD11b hi, CD103−, MHC class II+, Langerin− | Yes | 1, 2, 4, 6, 7, 8, 9, 13 | CCR1, CCR2, CCR4, CCR5, CXCR3, CXCR4 | CCR7, CXCR4 |
CD103+ DC | CD11c+, CD8α−, CD11b lo/−, CD103+, MHC class II+, Langerin+ | Yes | 2, 3, 4, 6, 9, 11, 12, 13 | ||||
pDC | pDC | CD11c int, CD11b lo/−, B220+, Ly6c+, MHC class II−/lo, SiglecH+ | Yes | 7, 9, 12 | |||
moDC | moDC | CD11c+, CD64+, CD11b hi, CD103−, MHC class II+, Langerin−, Ly6C+ | No | 3, 7, 8 | |||
Human | cDC | CD1c+ DC | CD1c+, CD11b+, CD11c+, CD13+, HLA-DR+, BDCA-1+ | Yes | 1, 2, 3, 4, 5, 6, 8, 10 | CCR1, CCR2, CCR4, CCR5, CCR6, CXCR1, CXCR4 | CCR7, CXCR4 |
CD141+ DC | CD141+, XCR1+, CLEC9A+, BDCA-3+ | Yes | 2, 3, 8 | ||||
pDC | pDC | CD11c dim, BDCA2+, BDCA4+, CD123+, l-selectin+, IL-3R+, HLA-DR−/lo | Yes | 7, 9 | |||
moDC | moDC | CD14+, HLA-DR+, CD1c−, CD141−, DC-SIGN+, CD163+ | No | 3, 7, 8 |
Definition of abbreviations: CCR, chemokine receptor; cDC, conventional DC; CXCR, C-X-C chemokine receptor; DC, dendritic cell; HLA-DR, human leukocyte antigen-antigen D related; MHC, major histocompatibility complex; moDC, monocyte-derived DC; pDC, plasmacytoid DC.