Table 1.

Summary of H₂S Treatment in Animal Models of Lung Diseases

Disease Model	H2S Donor(s)	Findings	References
Asthma (mouse, rat)	NaHS	↓ Airway hyperresponsiveness	(32)
		↓ Inflammation	(33)
		↓ Oxidative stress	(53)
		↓ Mast cell degranulation	(54)
		↓ Fibroblast recruitment and proliferation
		↓ Pathology
		↑ Lung function
COPD (mouse, rat)	NaHS	↓ Pathology	(39)
		↓ Inflammation	(40)
		↓ Airway hyperresponsiveness
		↑ Lung function
		↓ Oxidative stress
		↓ Apoptosis
Pulmonary fibrosis (mouse, rat)	NaHS	↓ Pathology	(56)
		↓ Oxidative stress	(57)
		↓ Inflammation	(58)
		↓ Fibrosis
Allergic rhinitis (guinea pig)	NaHS	↓ Clinical disease	(44)
		↓ Inflammation
Acute lung injury (mouse, rat)	DATS	↓ Inflammation	(61)
	GYY4137	↓ Oxidative stress	(65)
	DTT	↓ Clinical disease	(73)
RSV infection (mouse)	GYY4137	↓ Clinical disease	(50)
		↓ Airway hyperresponsiveness
		↓ Viral replication
		↓ Inflammation

Definition of abbreviations: COPD, chronic obstructive pulmonary disease; DATS, diallyl trisulfide; GYY4137, phosphorodithioate-based donor; DTT, 1,2-dithiole-3-thiones; NaHS, sodium hydrosulfide; RSV, respiratory syncytial virus.