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. 2017 Oct 20;12(10):e0184566. doi: 10.1371/journal.pone.0184566

Table 1. Clinical and pulmonary function primary baseline parameters.

    Control AP1 AP2 P
N   6 6 7  
Age   23.3 (4.1) 22.2 (3.7) 20.1 (2.0) 0.298
Male/Female   4/2 2/4 4/3 0.489 *
BMI         0.251 *
  <18.5 0.00 (0) 0.00 (0) 0.00 (0)  
  18.5–24.9 66.7 (4) 33.3 (2) 71.4 (5)  
  25.0–29.9 33.3 (2) 16.7 (1) 14.3 (1)  
  ≥ 30.0 0.00 (0) 50.0 (3) 14.3 (1)  
FEV1 (L)   3.9 (0.5) 3.5 (0.4) 3.1 (0.5) 0.063
FEV1 (% predicted)   94.6 (7.9) 89.8 (8.5) 76.4 (8.1) 0.006
FVC (L)   4.7 (0.6) 4.5 (0.7) 4.3 (0.9) 0.738
FEV1/FVC   0.82 (0.05) 0.79 (0.10) 0.73 (0.07) 0.129
Obstruction FEV1/FVC < LLN         0.042 *
  Normal   66.7 (4) 14.2 (1)  
  Mild   33.3 (2) 42.9 (3)  
  Moderate   0.00 (0) 42.9 (3)  
PD15+   0.00 (0) 100.0 (6) 100.0 (7) <0.001 *
PD15 (mg)     255(112–580) 73 (40–134) 0.012
ACQ Score         0.521 *
  <0.75   50.0 (3) 33.3 (2)  
  0.75–1.5   16.7 (1) 16.7 (1)  
  >1.5   33.3 (2) 50.0 (3)  
Bronchodilator Response         0.758 *
ΔFEV1 (L) < 0.2 L 83.3 (5) 66.7 (4) 66.7 (4)  
ΔFEV1 (L) > 0.2 L 16.7 (1) 33.3 (2) 33.3 (2)  
SPT+   50.0 (3) 100.0 (6) 100.0 (7) 0.021 *

Continuous variables reported as mean (standard deviation) and categorical variable reported as percentage (N). Asthma phenotype (AP) 1 and 2, body mass index (BMI), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and lower limit of normal as determined by ATS/ERS guidelines 5] (LLN), positive mannitol bronchial provocation test (PD15 +), provocation dose mannitol bronchial provocation test (PD15), asthma control questionnaire (ACQ), positive skin prick test (SPT+).

* Significance determined by Chi-square analysis with boot-strap approximation of distribution