Fig 5. GK rat glucagon but not insulin affected by 28 days treatment with AgoPAMs or partial agonist.

Little effect on insulin was seen in any treatment group (A). Treatment with AgoPAMs caused a significant and sustained increase in glucagon, while MK-8666 showed a trend of increasing glucagon at 28 days (B). Data are mean ± SEM with analysis via ANOVA followed by Tukey’s posttest. * P < 0.05 vs. Vehicle; ⁺ P < 0.05 vs. MK-8666.