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. 2017 Oct 20;12(10):e0186033. doi: 10.1371/journal.pone.0186033

Fig 7. GLP-1R-/- mice vs. wild type mice during an IPGTT.

Fig 7

After treatment with MK-2305 at 10 mg/kg or AP1 at 30 mg/kg and a dextrose challenge, blood glucose excursion was reduced to similar levels in both the knockout and wild type mice compared to the respective vehicle groups (A, B). AP1 administered at a maximally efficacious dose increased insulin following the dextrose challenge in both knockout and wild type mice, but a much greater effect was seen in the wild type mice (C, D). The partial agonist MK-2305 administered at a maximally efficacious dose showed no effect in insulin for either the knockout or wild type mice. Data are mean ± SEM with analysis via ANOVA followed by Tukey’s posttest. ^ P < 0.05 vs. GLP-1R-/- Vehicle; * P < 0.05 vs. WT Vehicle; + P < 0.05 vs. GLP-1R-/- AP1.