Table 3. Prevalence of deleterious variants within subgroups.
| Subgroup | n |
BRCA1/2 positive n (%) |
risk genes n (%) |
any gene n (%) |
|---|---|---|---|---|
| All (%) | 523 | 109 (20.8) | 138 (26.4) | 146 (27.9) |
| Age* | ||||
| < 60 years | 268 | 81 (30.2) | 89 (33.2) | 94 (35.1) |
| ≥ 60 years | 254 | 27 (10.6) | 48 (18.9) | 51 (20.1) |
| Family history | ||||
| Positive | 225 | 71 (31.6) | 81 (36.0) | 82 (36.4) |
| Negative | 289 | 33 (11.4) | 51 (17.6) | 58 (20.1) |
| Histologic subtype* | ||||
| High grade serous (HGS) | 406 | 94 (23.2) | 118 (29.1) | 123 (30.3) |
| other | 108 | 11 (10.2) | 16 (14.8) | 18 (16.7) |
| Within subset of HGS | ||||
| Primary diagnosis | 203 | 46 (22.7) | 54 (26.6) | 57 (28.1) |
| Relapse | 203 | 48 (23.6) | 64 (31.5) | 66 (32.5) |
* Age class was missing for 1 patient; histologic subtype was missing for 9 patients.