Table 2. Calculation of binding site properties of wild and T164I variant β2AR.

Binding site topology	Wild	T164I variant	T164I variant /Wild	Surface/Volume for Wild	Surface/ Volume for T164I variant
Volume [ų]	404.48	520.70	1.28	1.67	1.60
Surface [Ų]	676.52	834.92	1.23
Depth [Å]	22.72	32.67	1.43
Functional group descriptors (n)
Hydrogen bond donors	26	18
Hydrogen bond acceptors	116	112
Metals	0	0
Hydrophobic interactions	114	82