Table 4. Interaction profile of salbutamol in wild and T164I variant of β2AR.
Wild | T164I variant | |||
---|---|---|---|---|
# of contacts | Interacting Residues | # of contacts | Interacting Residues | |
H bonds | 5 | 2(Asp 113), Asn 312, Ser 203, Ser 207 | 2 | Asp 113, Thr 118 |
pi-pi stacking | 1 | Phe 193 | 1 | Phe193 |
Salt bridges | 0 | 0 | ||
Electrostatic contacts | 8 | Asp 113,Val 114, Tyr 316, Asn 312, Ser 203, Ser 204, Ser 207, Asn 293 | 7 | Asp 113,Val 114, Thr 118, Ser 203, Ser 207, Asn 312, Tyr 316 |
van der Waal contacts | 11 | Met 82, Trp 109, Thr 110, Val 117, Thr 118, Phe 193, Phe 208, Trp 286, Phe 289, Phe 290, Tyr 308 | 9 | Met 82, Thr 110, Phe 193, Trp 109, Phe 289, Phe 290, Ser 204, Trp 286, Val 117 |