Figure 7.

(a) Bar plot demonstrate the selectivity of S6 RNA aptamer and anti-HER2/c-erb-2 conjugated graphene oxide for SKBR3 cell based on the 1350 cm⁻¹ ‘D’ Raman band at different incubation time. (b) Bar graph indicates, doubly functionalized graphene oxide with S6 RNA aptamer and anti-HER2/c-erb-2 is about 6 times more sensitive then singly functionalized one, and Raman band from the solution mixture disappears under 532 nm excitation where as it is still visible under 670 nm excitation indicates internalization through cell membrane of the SKBR3. (c) Number of cell verses Raman intensity of ‘D’ band of functionalized graphene oxide at 532 nm laser excitation and 670 nm excitation indicates that using 532 nm green laser, ~ 60 SKBR3 cells can be detected with excellent discrimination over LNCaP cell and HaCaT cell.