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. 2017 Jul 27;8(43):73372–73386. doi: 10.18632/oncotarget.19637

Figure 2. LSD1 overexpression promotes OSCC growth and metastasis.

Figure 2

A. HSC-3-LSD1 cells implanted into the tongue of nude mice (n = 5 per condition) grew more than HSC-3-control cells, as evaluated by caliper measurements; B. An in vivo imaging system (IVIS) revealed that on day 17 post-implantation, tumors derived from HSC-3-LSD1 and HSC-3-control cells appeared similar whereas by day 24, the tumors derived from HSC-3-LSD1 cells displayed increased growth and metastasis; C. IVIS imaging of extracted internal organs demonstrating tongue tumor growth and metastasis and D. RT-qPCR analysis of LSD1 expression. E. ShLSD1-HSC-3 cells implanted into the tongue of nude mice (n = 8 per condition) grew dramatically less than HSC-3-control cells, as evaluated by caliper measurements; F. IVIS on day 17 post-implantation revealed only a slight difference in HSC-3-LSD1-derived tumors compared to HSC-3-derived tumors whereas by day 24, HSC-3-LSD1 tumors showed reduced growth and metastasis; G. IVIS imaging of extracted internal organs demonstrating tongue tumor growth and metastasis and H. RT-qPCR analysis of LSD1 expression. Statistical analyses were performed with unpaired Student’s t-tests. * P-value<0.05.