A. Concentration of TSP-1, TGF-β1, CTGF and VEGF proteins in the supernatants of RA-FLS culture after TSP-1, TGF-β1, CTGF and VEGF stimulation or knockdown.

Protein	+CTGF	+ TGF-β1	+ TSP-1	+ VEGF	CTGF siRNA	TGF-β1 siRNA	TSP-1 siRNA	VEGF siRNA
CTGF	3.99±0.14 ***	1.51±0.02 **	0.96±0.02	1.57±0.02 **	0.33±0.01 ##	0.75±0.02 #	0.98±0.02	0.68±0.01 #
TGF-β1	1.01±0.03	1.33±0.03 *	1.04±0.03	1.99±0.08 **	1.03±0.04	0.23±0.01 ###	1.07±0.04	0.72±0.01 ##
TSP-1	1.48±0.05 *	1.45±0.03 *	1.45±0.02 *	1.71±0.04 *	0.73±0.01 #	0.72±0.02 #	0.54±0.02 ##	0.48±0.01 ##
VEGF	1.74±0.07 **	3.61±0.20 **	0.99±0.03	1.94±0.05 **	0.42±0.01 ##	0.61±0.01 #	0.94±0.03	0.29±0.01 ##

Results are expressed as the mean ± S.E.M. Each intervention treatment group (n=3) was compared to its mock treatment control (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 versus vehicle control. # p < 0.05, ## p < 0.01, ### p < 0.001 versus scramble siRNA.