Table 3. Univariate and Multivariate Cox Regression analyses of baseline variables with renal outcome for ESRD.
| Variable (n=919) | Univariate Cox | Multivariate Cox | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P-value | |
| Age at biopsy (years) | 1.01(0.99-1.02) | 0.42 | 0.98(0.96-0.99) | 0.01* |
| Gender (Male) | 1.67(1.17-2.41) | 0.005* | 1.86(1.15-3.00) | 0.01* |
| eGFR (mL/min/1.73m2) | 0.96(0.95-0.96) | <0.001* | 0.97(0.96-0.98) | <0.001* |
| SBP (mm Hg) | 1.02(1.01-1.03) | <0.001* | 1.00(0.99-1.01) | 0.83 |
| DBP (mm Hg) | 1.03(1.02-1.04) | <0.001* | -- | -- |
| Blood urea nitrogen (mg/dL) | 1.07(1.06-1.08) | <0.001* | 1.02(0.99-1.05) | 0.14 |
| Serum uric acid (mg/dL) | 1.52(1.40-1.66) | <0.001* | 1.07(0.92-1.24) | 0.37 |
| Serum albumin (g/dL) | 0.61(0.49-0.76) | <0.001* | -- | -- |
| Hypoalbuminemia (%) | 2.07(1.34-3.18) | 0.001* | 2.15(1.20-3.83) | 0.01* |
| Serum triglycerides (mg/dL) | 1.001(1-1.002) | 0.02* | 1.001(1-1.002) | 0.07 |
| Serum cholesterol (mg/dL) | 1.001(0.998-1.004) | 0.49 | -- | -- |
| Hemoglobin (g/dL) | 0.75(0.70-0.82) | <0.001* | 0.88(0.78-0.98) | 0.02* |
| WBC (103/mm3) | 0.93(0.86-1.02) | 0.12 | -- | -- |
| Serum IgA (mg/dL) | 1.001(0.999-1.002) | 0.48 | -- | |
| Serum C3 (mg/dL) | 0.99(0.98-1.00) | 0.005* | 1(0.99-1.01) | 0.92 |
| Urine protein excretion (g/24h) | 1.16(1.09-1.23) | <0.001* | -- | -- |
| Nephrotic range proteinuria (%) | 2.40(1.55-3.74) | <0.001* | 0.77(0.44-1.37) | 0.38 |
| Blood group (nonB-antigen) | 2.46(1.59-3.79) | <0.001* | 2.21(1.35-3.62) | 0.002* |
| Oxford Classification: M1 | 0.74(0.52-1.06) | 0.11 | -- | -- |
| Oxford Classification: E1 | 0.95(0.57-1.59) | 0.85 | -- | -- |
| Oxford Classification: S1 | 1.31(0.86-1.99) | 0.21 | -- | -- |
| Oxford Classification: T(1 increase) | 2.64(2.12-3.29) | <0.001* | 2.01(1.49-2.70) | <0.001* |
| Oxford Classification: T1 | 2.12(1.36-3.32) | 0.001* | -- | -- |
| Oxford Classification: T2 | 7.30(4.75-11.21) | <0.001* | -- | -- |
| ACEI or ARB treatment | 1.08(0.63-1.86) | 0.78 | -- | -- |
| Glucocorticoid treatment | 0.44(0.30-0.64) | <0.001* | 0.61(0.37-0.995) | 0.048* |
Note: Data are reported as hazard ratios (HRs) and 95% confidence intervals (CIs) ;*p<0.05.