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. 2017 May 11;8(43):73693–73704. doi: 10.18632/oncotarget.17793

Figure 2. MSCs treated with inflammatory factors increase the CCA cells migration and metastasis.

Figure 2

MSCs in inflammatory environment increase the migration ability of QBC939 (A) and Mz-chA-1 (B). MSC-CM: MSCs conditioned medium. MSC(TI)-CM: conditioned medium of MSCs pretreated with TNF-α and IFN-γ. MSC(TIP)-CM: conditioned medium of MSCs pretreated with TNF-α, IFN-γ and PDTC. (C) The image of xenograft tumor from each group (n = 4). (D) Tumor volume measurements of each group. (E) Representative gross image of mouse livers from each group. The black arrow indicate the tumor nodules. (F) The number of tumor nodules metastasize to livers. (G) Representative histology image of H&E staining of liver sections. *P < 0.05, **P < 0.01, ****P < 0.0001, ns: not significant; two-tailed Student’s t test. Abbreviations: PTDC: pyrrolidine dithiocarbamate.