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. 2017 May 16;8(43):73905–73924. doi: 10.18632/oncotarget.17879

Figure 1. DHS is more potent than Resv in inducing death in human neuroblastoma cells.

Figure 1

(A) Chemical structures of the test hydroxystilbenes. (B) Dose-dependent cytotoxic activity of DHS and Resv against IMR32 and SHSY-5Y cell lines. The cells were incubated with vehicle (0.1% DMSO) or increasing concentrations of DHS or Resv. Cell viability at 48 h was assessed by the MTT assay. (C) and (D) Clonogenic assay. The IMR32 and SHSY-5Y cells, pre-treated with vehicle or different concentrations of DHS or Resv were grown in petri-plates for 12 days, stained with 0.5% crystal violet, and the colonies of viable cells were scanned and counted. The viable colonies were determined considering that of the untreated cells as 100 after correcting the plating efficiency. All determinations were made in five replicates in 3-4 different experiments and the values are mean ± S. E. M. *p<0.05, **p<0.01, ***p<0.001 compared to vehicle control.