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. 2017 Jun 22;8(43):74006–74018. doi: 10.18632/oncotarget.18598

Figure 2. CBP501 prevents cell migration of H1299 cells by various EMT inducing factors.

Figure 2

(A) H1299 cells were treated over 72 h with CBP501(1 μM) in combination with various human (recombinant) migration-inducing factors; WNT mix (100 ng/mL WNT-3a and 100 ng/mL WNT-5a), 100 ng/mL IL-6, Growth Factor mix (GF mix; 500 ng/mL EGF, 50 ng/mL HGF, 200 ng/mL IGF-I and 100 ng/mL FGF). (B) (Left) H1299 cells were treated with WNT-3a or WNT-5a in combination with CBP501 for 72 h. (Right) H1299 cells were treated with EGF, HGF, IGF-I or FGF in combination with CBP501 for 72 h. (C) H1299 cells were treated with WNT-5a or EGF in combination with CBP501 or AG1478 for 72 h. (D) H1299 cells were treated with WNT-5a or IGF-I in combination with CBP501 or PQ401 for 72 h. Scale bar is 500 μm. Data, the mean ± SD; * and **, P < 0.05 and P < 0.005, respectively.