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. 2017 May 26;8(43):74119–74128. doi: 10.18632/oncotarget.18271

Figure 2. Functional analysis of SNPs and candidate genes associated with prostate cancer progression.

Figure 2

(A) Expression quantitative trait locus associations of rs9393682 and rs1378033 with nearby genes (HIST1H1C and HFE for rs9393682; SGCZ and TUSC3 for rs1378033) expression in prostate tissues (GTEx dataset). Numbers in parentheses indicate the number of cases. (B) Effect of 1,25-VD on candidate genes expression. PC-3 cells were treated with vehicle or 1,25-VD for indicated time points. Total mRNA was prepared and the corresponding gene expression was determined by qRT-PCR. Values represent the fold change in gene expression relative to vehicle-treated control. Asterisk indicates significant difference (P < 0.05). (C) Correlation of candidate genes expression with prostate cancer aggressiveness. Numbers in parentheses indicate the number of cases. (D) Kaplan-Meier analysis of progression-free survival based on candidate genes expression using an independent dataset from Sboner et al. Numbers in parentheses indicate the number of cases.