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. 2017 Jun 14;8(43):74209–74216. doi: 10.18632/oncotarget.18474

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Copyright: © 2017 Chen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The additive effects of the TM6SF2 E167K and PNPLA3 I148M polymorphisms on NAFLD may be associated with upregulating the expression of SREBP-1c and FASN. Abbreviations: SREBP-1c: sterol regulatory element-binding transcription factor 1c; FASN: fatty acid synthase; NAFLD: nonalcoholic fatty liver disease.