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. 2017 Jun 16;8(43):74217–74232. doi: 10.18632/oncotarget.18540

Figure 1. Effect of APX-115 on kidney function and morphology.

Figure 1

Diabetes was induced in mice by intraperitoneal injection of STZ (50 mg/kg). Then APX-115 (60 mg/kg/day) or losartan (1.5 mg/kg/day) was administered orally for 12 weeks to diabetic mice. After 12 weeks, urine and blood samples were collected for analysis of (A) urinary albumin excretion, (B) albumin/creatinine ratio, (C) creatinine clearance rate, and (D) plasma cystatin C. (E) Kidneys were fixed in paraffin and cut into 3 μm sections that were subsequently stained with PAS reagent. Scale bar: 10 μm; original magnification: 630×. After PAS staining, (F) glomerular volume, (G) mesangial area, and (H) tuft area were analyzed using Image-Pro Plus 4.5.1. DM, STZ-induced diabetic mice. Data are presented as means ± SE of 10–12 mice/group; *p < 0.05 vs. control, †p < 0.05 vs. DM.