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. 2017 Jul 19;8(43):74276–74286. doi: 10.18632/oncotarget.19395

Figure 4. ZNRF3 gene was identified as a direct target of miR-146a.

Figure 4

(A) 6 target genes of miR-146a were identified by miRNA forecasting software. (B) Diagrams demonstrated the miR-146a putative binding sites and corresponding mutant sites of ZNRF3. (C) The expression levels of ZNRF3 were examined after transfection with miR-146a by qRT-PCR and Western blotting assays in MG-63 and HOS cells. (D) Luciferase activity of ZNRF3 (wild type or mutation) was evaluated after miR-146a transfection into MG-63 and HOS cells. **P<0.01.