Figure 5. Changes in protein expressions of oxidative and DNA damage markers at 30 days in mice with chronic cerebral hypoperfusion.

(A) Illustration of Western blot results of ROS (i.e., NOX-I and NOX-II) and r-H₂A. (B) Protein expression of NOX-I; (C) Protein expression of NOX-II;. (D) Protein expression of r-H₂A; All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. The p < 0.05 indicates statistical significance between two groups. SC = sham control; CHP = cerebral hypoperfusion; CHP-Mela = cerebral hypoperfusion with melatonin (10 mg/kg/day,ip); CHP-Mela-Luz = cerebral hypoperfusion with melatonin (10 mg/kg/day, ip) and luzindole (30 mg/kg, ip).