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. 2017 Aug 12;8(43):74582–74594. doi: 10.18632/oncotarget.20216

Figure 6. BPIS attenuated inflammatory responses in colon cell xenograft tumor models.

Figure 6

Colon cancer cells were implanted subcutaneously in the right flank of male nude mice. (A) Western blot analysis. Effects of BPIS on expression of p-Akt, NF-κB-p65 and inflammatory cytokines protein levels. Columns were expressed as mean±SEM (n = 3, *p<0.05 vs. control). (B) Relative gene expression levels were normalized to GAPDH expression levels by qRT-PCR. (C) Immunohistochemical analysis of the expression of Akt phosphorylation and NF-κB-p65 in colon cancer tissues by BPIS treatment group or control group. (D) Columns were expressed as mean±SEM (n = 3, *p<0.05 vs. control). (E) qRT-PCR analysis of miR-149 in vivo. Data were presented as mean ± SEM (n=10, *p<0.05 vs. control).