Table 1. Meta-analysis of four independent SNPs in MDACC and Harvard databases.
| SNP | Allelea | Gene | MDACC (n=858)b | Harvard (n=409)c | Meta-analysisd | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | Phet | I2(%) | HR (95%CI) | P | |||
| rs6707820 | C>T | NCK2 | 2.19 (1.48-3.25) | 9.53E-05 | 1.34 (0.76-2.37) | 0.310 | 0.164 | 48.4 | 1.87 (1.35-2.59) | 1.53E-05 |
| rs2306574 | T>C | PRKCD | 1.92 (1.40-2.64) | 6.46E-05 | 1.31 (0.86-2.19) | 0.181 | 0.242 | 27.1 | 1.73 (1.33-2.24) | 4.56E-06 |
| rs2645768 | A>C | COL6A3 | 1.91 (1.41-2.58) | 2.40E-05 | 0.65 (0.37-1.14) | 0.131 | 0.001 | 90.9 | 1.14 (0.40-3.29) | 0.801 |
| rs13301426 | C>T | COL5A1 | 2.36 (1.53-3.64) | 9.54E-05 | 1.05 (0.52-2.14) | 0.903 | 0.056 | 72.7 | 1.66 (0.75-3.64) | 0.210 |
MDACC: The University of Texas M.D. Anderson Cancer Center; HR: hazards ratio; CI: confidence interval; Phet: P-value for heterogeneity test, SNP: single nucleotide polymorphism.
aReference allele/effect allele.
bAdjusted for age, sex, Breslow’s tumor thickness, regional/distant metastasis, ulceration and mitotic rate.
cAdjusted for age and sex.
dIf Phet <0.10 or I2>50%, random-effects model was selected; otherwise fixed-effect model was selected.