Table 4. Associations in stratified analysis of MSS and NUG across genes in the MDACC study.
| Characteristics | 0 NUGsa | 1-2 NUGsa | Multivariate analysisb | Pinteractionc | |||
|---|---|---|---|---|---|---|---|
| All | Death (%) | All | Death (%) | HR (95% CI) | P | ||
| Age | 0.154 | ||||||
| ≤50 | 183 | 7 (3.8) | 188 | 24 (12.8) | 4.25 (1.73-10.49) | 0.002 | |
| >50 | 230 | 24 (10.4) | 257 | 40 (15.6) | 1.86 (1.10-3.16) | 0.021 | |
| Sex | 0.874 | ||||||
| Female | 180 | 9 (5.0) | 182 | 17 (9.3) | 2.67 (1.13-6.30) | 0.025 | |
| Male | 233 | 22 (9.4) | 263 | 47 (17.9) | 2.37 (1.40-4.00) | 0.001 | |
| Regional/distant metastasis | 0.104 | ||||||
| No | 342 | 17 (5.0) | 367 | 34 (9.3) | 1.84 (1.01-3.34) | 0.046 | |
| Yes | 71 | 14 (19.7) | 78 | 30 (38.5) | 3.40 (1.72-6.72) | <0.001 | |
| Breslow's tumor thickness (mm) | 0.221 | ||||||
| ≤1 | 174 | 3 (1.7) | 173 | 4 (2.3) | 0.65 (0.11-3.72) | 0.626 | |
| 1-2 | 140 | 9 (6.4) | 136 | 17 (12.5) | 2.14 (0.93-4.91) | 0.074 | |
| 2-4 | 64 | 13 (20.3) | 103 | 28 (27.2) | 1.72 (0.87-3.42) | 0.120 | |
| >4 | 35 | 6 (17.1) | 33 | 15 (45.5) | 3.36 (1.25-9.03) | 0.016 | |
| Ulceration | 0.068 | ||||||
| No | 335 | 18 (5.4) | 346 | 30 (8.7) | 1.66 (0.92-2.99) | 0.090 | |
| Yes | 70 | 13 (18.6) | 85 | 30 (35.3) | 3.79 (1.88-7.62) | <0.001 | |
| Missing | 22 | ||||||
| Mitotic rate (mitoses/mm2) | 0.398 | ||||||
| <1 | 132 | 3 (2.3) | 143 | 6 (4.2) | 1.68 (0.40-7.08) | 0.481 | |
| ≥1 | 281 | 28 (10.0) | 302 | 58 (19.2) | 2.10 (1.34-3.30) | 0.001 | |
MSS: melanoma-specific survival; NUG, number of risk genotype; MDACC: The University of Texas M.D. Anderson Cancer Center; HR: hazards ratio; CI: confidence interval.
anumber of risk genotypes were derived from rs2306574 CC+CT and rs6707820 TT+CT.
bMultivariate Cox regression analyses were adjusted for age, sex, Breslow thickness, distant/regional metastasis, ulceration of tumor and tumor cell mitotic rate, where appropriate.
cP-value for multiplicative interaction.