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. 2017 Aug 16;8(43):74635–74648. doi: 10.18632/oncotarget.20287

Figure 2. The role of IGFBP-2 in hyperglycaemia-induced chemo-resistance.

Figure 2

MCF-7 cells (A) and T47D cells (B) were incubated in different glucose conditions (5mM, 9mM and 25mM) and treated in the presence and absence of IGFBP-2 siRNA. The cells were treated with 1μM doxorubicin. Cell death was measured by a trypan blue dye exclusion assay. Inserts: IGFBP-2 abundance in 5, 9, 25mM glucose in the presence and absence of IGFBP-2 siRNA where the total cell extract was analysed by Western immunoblotting. The graph represents the mean±SEM of three independent repeats each conducted in triplicate; NS= non-silencing siRNA, BP2= IGFBP-2 siRNA.