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. 2017 Aug 18;8(43):74673–74687. doi: 10.18632/oncotarget.20341

Figure 6. Metformin inhibited the transition of NECs toward TECs by blocking JAK/STAT3/c-MYC signaling pathway.

Figure 6

(A) NECs were induced by KYSE450 or KYSE70 TCM with or without metformin for 48 h. The relative mRNA levels of JAK, STAT3 and c-MYC were analyzed by qRT-PCR. (B) Western blot was done to detect the expression levels of indicated proteins. (C and D) The mRNA and protein levels of TECs markers (TEM1, TEM8 and VEGFR2) were detected by qRT-PCR (C) and Western blot (D). Data are shown as mean ± SD. * p < 0.05, ** p < 0.01, *** p < 0.001.