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. 2017 Aug 18;8(43):74703–74719. doi: 10.18632/oncotarget.20345

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Copyright: © 2017 Xu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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HCA and PCA of genes pertaining to glycolysis (A), TCA cycle and sirtuin pathways (B), and five mitochondrial respiratory chain complexes (C). (A) Majority of tumors were clustered together within the upregulated side (red) of glycolytic HCA. Tumor is marked with red dendrogram and normal sample is marked with blue dendrogram. The bold dendrograms in HCA mark subgroups of tumors with the greatest upregulated corresponding genes. Both high stage tumors (labeled in red) and low stage tumors (labeled in black) are presented in bold dendrograms. Tumors were more heterogeneous than normal controls in PCA plot. (B) and (C) Majority of tumors were clustered together within the downregulated side (blue) of TCA/ SIRT pathway and mitochondrial respiratory chain complexes. Tumor is marked with blue dendrogram and normal sample is marked with red dendrogram. The bold dendrograms in HCAs mark subgroups of tumors with the greatest downregulated corresponding genes. Both high stage tumors (labeled in red) and low stage tumors (labeled in black) are presented in bold dendrograms. Tumors were more heterogeneous than normal controls in PCA plots.

HCA and PCA of genes pertaining to glycolysis (A), TCA cycle and sirtuin pathways (B), and five mitochondrial respiratory chain complexes (C). (A) Majority of tumors were clustered together within the upregulated side (red) of glycolytic HCA. Tumor is marked with red dendrogram and normal sample is marked with blue dendrogram. The bold dendrograms in HCA mark subgroups of tumors with the greatest upregulated corresponding genes. Both high stage tumors (labeled in red) and low stage tumors (labeled in black) are presented in bold dendrograms. Tumors were more heterogeneous than normal controls in PCA plot. (B) and (C) Majority of tumors were clustered together within the downregulated side (blue) of TCA/ SIRT pathway and mitochondrial respiratory chain complexes. Tumor is marked with blue dendrogram and normal sample is marked with red dendrogram. The bold dendrograms in HCAs mark subgroups of tumors with the greatest downregulated corresponding genes. Both high stage tumors (labeled in red) and low stage tumors (labeled in black) are presented in bold dendrograms. Tumors were more heterogeneous than normal controls in PCA plots.