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. 2017 Aug 18;8(43):74703–74719. doi: 10.18632/oncotarget.20345

Table 2A. Discrepancy between histological diagnosis and molecular profiles.

Dysregulated biological processes A few tumors clustered with most normal samples A few normal samples clustered with most tumors
High stage tumors Low stage tumors Normal samples adjacent to high stage tumors Normal samples adjacent to low stage tumors
upregulated response to interferon-gamma (10 genes) 0 0 N8 N36, N41, N66, N76
upregulated collagen catabolic process (24 genes) 0 0 N8 0
upregulated chemokines mediated signaling pathways (18 genes) T57, T63 T70 N15, N34, N56 0
upregulated inflammatory response (56 genes) 0 0 N8 0
upregulated cell proliferation (50 genes) 0 0 N56 N41
upregulated immune response (51 genes) 0 0 0 0
upregulated glycolysis (6 genes) T9, T51, T27 0 N56, N49, N50, N21, N34, N2 N1, N18, N36, N41, N42, N76
upregulated hub genes (5 genes) T9, T46, T51 T2, T20 N56 0
downregulated cellular response to cadmium (9 genes) T51 T20, T31 N8, N49, N56 N41, N76
downregulated acid beta-oxidation (16 genes) 0 0 N8, N56, N58 0
downregulated xenobiotic metabolic process (18 genes) 0 T20 N8, N58 0
downregulated epithelial cell differentiation (16 genes) 0 T20 N8, N58 0
downregulated SIRT and TCA cycle (11 genes) 0 0 N3, N8, N57, N58 N1
downregulated respiratory chain (67 genes) T34 0 N8, N58 0
downregulated hub genes (5 genes) 0 0 N8, N58 N41