Table 2B. Low stage tumors and normal samples show similar gene expression profiles with high stage tumors.
| Dysregulated biological processes | Tumors and normal samples clustered within high expression zones | ||
|---|---|---|---|
| High stage tumors | Low stage tumors | Normal samples adjacent to high stage tumors | |
| upregulated response to interferon-gamma | T6, T14, T16, T25, T26, T46, T47, T55 | T1, T2, T10, T13, T41, T68 | 0 |
| upregulated collagen catabolic process | T44, T48, T55, T56, T74, T75, T79 | T38, T72, T76 | 0 |
| upregulated chemokines mediated signaling pathways | T6, T15, T26, T47 | T1, T40, T68 | 0 |
| upregulated inflammatory response | T14, T15, T48 | T1, T17, T38 | 0 |
| upregulated cell proliferation | T25, T74, T50, T78, T79 | T17,T65, T72, T76 | 0 |
| upregulated immune response | T6, T15,, T26, T45, T47, T50 | T1, T17, T40 | 0 |
| upregulated glycolysis | T4, T26, T44, T45, T48, T75 | T33, T37, T41, T42, T71 | 0 |
| upregulated hub genes | T3, T47, T56, T74 | T40 | 0 |
| Tumors and normal samples clustered within low expression zones | |||
|---|---|---|---|
| Dysregulated biological processes | High stage tumors | Low stage tumors | Normal samples adjacent to high stage tumors |
| downregulated acid beta-oxidation | T9, T12, T21, T46, T51, T62, T57, T58, T59, T77, T80 | T36 | N8, N58 |
| downregulated xenobiotic metabolic process | T4, T5, T35, T8, T14, T49, T52, T56, T58, T74, T75, T79, T80 | T38, T76 | N8, N58 |
| downregulated epithelial cell differentiation | T3, T4, T8, T52, T56 | T38, T40 | N8 |
| downregulated SIRT and TCA cycle | T9, T12, T19, T35, T48, T51 | T1, T2, T10, T38 | N8, N58 |
| downregulated respiratory chain | T6, T21, T48, T80 | T38 | 0 |
| downregulated hub genes | T3, T4, T8, T52, T56, T80 | T38 | N8 |