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. 2017 Aug 24;8(43):74791–74805. doi: 10.18632/oncotarget.20422

Figure 4. DATS treatment significantly reduced myocardial infarct size and inhibited myocardial apoptosis, which was blunted by Compound C or LY294002 co-administration.

Figure 4

(A) and (B). Myocardial infarct size; (C). Representative photomicrographs of TUNEL staining (×200, bar=200μm). Apoptotic nuclei were stained with TUNEL (Row 1). Total nuclei were stained with DAPI (Row 2). (D). Percentage of TUNEL positive nuclei; (E). representative blots; (F). cleaved caspase-3 expression; (G). Bcl-2 expression; (H). Bax expression. Data are expressed as mean ± SEM, n = 6 in each group; **P < 0.01/*P < 0.05 vs the T1D+Sham group, ##P < 0.01/#P < 0.05 vs the T1D+MI/R+V group, $$P < 0.01/$P < 0.05 vs the T1D+MI/R+DATS group. T1D, type 1 diabetes; MI/R, myocardial ischemia-reperfusion; DATS, diallyl trisulfide; Com.C, Compound C; LY, LY294002.