Table 2. Cabozantinib downregulated genes that are involved in the “differentiation of osteoblastic-lineage cells”.
| Symbol | Gene Name | Fold Change | p-value | Location | Family |
|---|---|---|---|---|---|
| DLK1 | delta-like 1 homolog (Drosophila) | -9.30 | 0.010 | Extracellular Space | **other |
| ELF4 | E74 like ETS transcription factor 4 | -2.58 | 0.003 | Nucleus | transcription regulator |
| HDAC4 | histone deacetylase 4 | -2.27 | 0.022 | Nucleus | transcription regulator |
| RORB | RAR related orphan receptor B | -2.20 | 0.016 | Nucleus | ligand-dependent nuclear receptor |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.08 | 0.018 | *Other | other |
| IL11 | interleukin 11 | -2.12 | 0.007 | Extracellular Space | cytokine |
| CD200 | CD200 molecule | -2.23 | 0.002 | Plasma Membrane | other |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -2.29 | 0.018 | Plasma Membrane | kinase |
| BMP6 | bone morphogenetic protein 6 | -2.79 | 0.042 | Extracellular Space | growth factor |
| SFRP4 | secreted frizzled related protein 4 | -3.56 | 0.004 | Plasma Membrane | transmembrane receptor |
| IFI16 | interferon gamma inducible protein 16 | -4.48 | 0.018 | Nucleus | transcription regulator |
| VCAN | versican | -2.01 | 0.023 | Extracellular Space | other |
| FLT4 | fms related tyrosine kinase 4 | -2.83 | 0.035 | Plasma Membrane | transmembrane receptor |
| PTK2 | protein tyrosine kinase 2 | -3.62 | 0.008 | Cytoplasm | kinase |
* The location of the protein has not been defined.
** The function of the protein has not been assigned.