Table 4. Cabozantinib upregulated genes that encode secreted factors.
| Symbol | Gene Name | Fold Change | p-value | Family |
|---|---|---|---|---|
| NELL1 | neural EGFL like 1 | 2.794 | 9.25E-04 | growth factor |
| TGFB1 | transforming growth factor beta 1 | 3.164 | 1.11E-03 | growth factor |
| NTF4 | neurotrophin 4 | 2.059 | 2.75E-02 | growth factor |
| LEFTY1 | left-right determination factor 1 | 3.53 | 4.22E-02 | growth factor |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 2.229 | 4.71E-02 | growth factor |
| IFNG | interferon, gamma | 4.285 | 4.44E-03 | cytokine |
| Ccl27a | chemokine (C-C motif) ligand 27A | 3.589 | 1.31E-02 | cytokine |
| IBSP | integrin binding sialoprotein | 3.218 | 1.64E-05 | **other |
| FAM3A | family with sequence similarity 3 member A | 2.882 | 6.53E-04 | other |
| WISP1 | WNT1 inducible signaling pathway protein 1 | 2.285 | 2.88E-03 | other |
| FAM132B | family with sequence similarity 132 member B | 3.75 | 2.93E-03 | other |
| WFDC1 | WAP four-disulfide core domain 1 | 2.395 | 2.99E-03 | other |
| MEPE | matrix extracellular phosphoglycoprotein | 2.035 | 3.23E-03 | other |
| CFC1/CFC1B | cripto, FRL-1, cryptic family 1 | 6.786 | 4.16E-03 | other |
| AIM1L | absent in melanoma 1-like | 2.13 | 4.82E-03 | other |
| RASAL2 | RAS protein activator like 2 | 2.119 | 4.96E-03 | other |
| VMO1 | vitelline membrane outer layer 1 homolog (chicken) | 3.936 | 6.43E-03 | other |
| FBLN1 | fibulin 1 | 2.316 | 7.85E-03 | other |
| ITIH4 | inter-alpha-trypsin inhibitor heavy chain family member 4 | 2.663 | 8.95E-03 | other |
| Hamp/Hamp2 | hepcidin antimicrobial peptide | 5.98 | 1.18E-02 | other |
| SMTN | smoothelin | 3.985 | 1.29E-02 | other |
| BPIFB2 | BPI fold containing family B member 2 | 2.534 | 1.62E-02 | other |
| IGFBP2 | insulin like growth factor binding protein 2 | 5.033 | 1.91E-02 | other |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 2.148 | 1.98E-02 | other |
| Fcna | ficolin A | 2.125 | 2.05E-02 | other |
| MFAP4 | microfibrillar associated protein 4 | 2.188 | 2.06E-02 | other |
| OLFML3 | olfactomedin like 3 | 3.071 | 2.36E-02 | other |
| KLHL5 | kelch like family member 5 | 3.402 | 2.49E-02 | other |
| CRB2 | crumbs family member 2 | 2.055 | 2.57E-02 | other |
| IFT22 | intraflagellar transport 22 | 2.547 | 2.73E-02 | other |
| VSTM2A | V-set and transmembrane domain containing 2A | 2.168 | 2.84E-02 | other |
| IL34 | interleukin 34 | 2.859 | 2.95E-02 | other |
| IFT172 | intraflagellar transport 172 | 5.1 | 2.99E-02 | other |
| WNT16 | wingless-type MMTV integration site family member 16 | 3.806 | 3.14E-02 | other |
| ADAMTSL1 | ADAMTS like 1 | 4.286 | 3.24E-02 | other |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | 3.193 | 3.39E-02 | other |
| APCS | amyloid P component, serum | 3.698 | 3.47E-02 | other |
| SLIT3 | slit guidance ligand 3 | 2.855 | 3.55E-02 | other |
| COL11A2 | collagen, type XI, alpha 2 | 4.198 | 3.68E-02 | other |
| PYY | peptide YY | 3.351 | 4.03E-02 | other |
| WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 | 2.424 | 4.27E-02 | other |
| KDM6B | lysine (K)-specific demethylase 6B | 2.073 | 4.30E-02 | other |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | 2.188 | 4.32E-02 | other |
| SERPINE1 | serpin peptidase inhibitor | 2.171 | 4.61E-02 | other |
| COL22A1 | collagen, type XXII, alpha 1 | 2.628 | 4.93E-02 | other |
| LIPI | lipase, member I | 9.486 | 4.79E-04 | enzyme |
| GFOD2 | glucose-fructose oxidoreductase domain containing 2 | 2.93 | 6.91E-04 | enzyme |
| FUCA2 | fucosidase, alpha-L- 2, plasma | 2.088 | 3.22E-02 | enzyme |
| LOXL1 | lysyl oxidase like 1 | 2.721 | 4.61E-02 | enzyme |
| PAPPA2 | pappalysin 2 | 12.557 | 4.50E-04 | peptidase |
| MMP8 | matrix metallopeptidase 8 | 3.24 | 5.39E-04 | peptidase |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 2.062 | 1.81E-03 | peptidase |
| CPXM2 | carboxypeptidase X (M14 family), member 2 | 2.846 | 6.45E-03 | peptidase |
| CPB1 | carboxypeptidase B1 | 2.991 | 1.32E-02 | peptidase |
| CPA3 | carboxypeptidase A3 | 3.977 | 1.47E-02 | peptidase |
| CPB2 | carboxypeptidase B2 | 2.243 | 2.09E-02 | peptidase |
| CPA4 | carboxypeptidase A4 | 3.1 | 2.36E-02 | peptidase |
| ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif 8 | 2.221 | 2.59E-02 | peptidase |
| Prss32 | protease, serine 32 | 4.528 | 2.69E-02 | peptidase |
| LTF | lactotransferrin | 2.479 | 3.14E-02 | peptidase |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 2.491 | 4.84E-02 | peptidase |
| BPGM | bisphosphoglycerate mutase | 2.414 | 3.26E-02 | phosphatase |
| A2M | alpha-2-macroglobulin | 2.54 | 3.52E-02 | transporter |
** The function of the protein has not been assigned.