Figure 5. Effects of 4NQO and 4NQO + nicotine on Prx1, α3nAChR, α7nAChR, apoptosis and MAPK in Prx1 wild-type (Prx1^+/+) mice.

(A) mRNA expression of α3nAChR, α7nAChR and Prx1; (B) protein expression of α3nAChR, α7nAChR and Prx1; (C) expression of Prx1 and α7nAChR detected by IHC; (D) apoptosis detected by TUNEL and Bcl-2 expression; (E) phosphorylation of p38, JNK and ERK1/2. The values are expressed as mean; bars, ± SE. * P < 0.05; ** P < 0.01.