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. 2017 Aug 24;8(43):75065–75075. doi: 10.18632/oncotarget.20506

Figure 6. Effects of 4NQO and 4NQO + nicotine on Prx1, apoptosis and MAPK in Prx1 knockdown (Prx1+/-) mice.

Figure 6

(A) mRNAexpression of Prx1; (B) apoptosis detected by TUNEL and Bcl-2 expression in animals treated with 4NQO; (C) protein expression of Prx1, p-p38, p-JNK and p-ERK1/2 in animals treated with 4NQO; (D) apoptosis detected by TUNEL and Bcl-2 expression in Prx1 knockdown mice treated with 4NQO or 4NQO plus nicotine; and (E) protein expression of Prx1, p-p38, p-JNK and p-ERK1/2 in Prx1 knockdown mice treated with 4NQO or 4NQO plus nicotine. The values are expressed as mean; bars, ± SE. * P < 0.05; ** P < 0.01.