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. 2017 Sep 8;8(43):75308–75325. doi: 10.18632/oncotarget.20779

Figure 1. Metformin treatment ameliorated the infarct volume and brain edema in HI brain injury.

Figure 1

(A) Representative TTC stained coronal brain sections from Sham, vehicle-treated HI and metformin-treated HI groups at 24 h after HI were shown. Number of animals, n=5 for each group. (B) Quantitative analysis of infarct volume; results were expressed as infarct area/ total area of the ipsilateral hemisphere. **P < 0.01 versus the sham group. ##P < 0.01 versus the HI group. Values represent the mean±SEM, Number of animals. n=5 for each group. (C) Quantification of brain water content in the ipsilateral brain hemisphere at 24 h after HI. **P< 0.01 versus the sham group. #P < 0.05 versus the HI group. Values represent the mean±SEM. Number of animals, n=5 for each group.