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. 2017 Sep 8;8(43):75308–75325. doi: 10.18632/oncotarget.20779

Figure 3. Metformin treatment prevented the degradation of tight junction and adherens junction proteins after HI injury.

Figure 3

Representative western blots of adherens junction proteins (P120, VE-Cadherin and β-Catenin) in the cortex (A) and hippocampus (E) at 24 h after HI injury. (B and F) Quantification of western blot data from A and E. *P< 0.05, **P < 0.01, ***P < 0.001 versus the sham group. #P< 0.05, ###P < 0.001versus the HI group. Values represent the mean±SEM, Number of animals. n=5 for each group. Representative western blots of adherens junction proteins (Occludin and Claudin-5) in the cortex (C) and hippocampus (G) at 24 h after HI injury. (D, H) Quantification of western blot data from C and G. *P< 0.05, **P < 0.01, ***P < 0.001 versus the sham group. #P< 0.05, ##P < 0.01 versus the HI group. Values represent the mean±SEM, Number of animals. n=5 for each group.