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. 2017 Sep 8;8(43):75308–75325. doi: 10.18632/oncotarget.20779

Figure 9. Metformin treatment attenuated brain atrophy, enhanced axonal repairation and promoted remyelination after HI injury.

Figure 9

Rats were treated with metformin daily for 7 consecutive days, and the brains from each group were acquired at 7 d post HI injury. (A) General observation of rat brain from each group at 7 d after HI injury. Scale bar = 1 cm. (B-C) Representative images of immunohistochemical staining for MAP-2 (B) and MBP (C). Scale bar = 200 μm. (D) Representative western blots of MAP-2 and MBP. (E-F) Quantification of ipsilateral MAP-2 and MBP area loss. **P < 0.01 versus the sham group. #P < 0.05, ##P < 0.01 versus the HI group. Values represent the mean±SEM, Number of animals. n=5 for each group. (G) Quantification of western blot data from D. **P < 0.01 versus the sham group. #P < 0.05, ##P < 0.01 versus the HI group. Values represent the mean±SEM, Number of animals. n=5 for each group.