Table 1. Results of meta-regression.

Parameter	Sensitivity		Specificity		Joint model
	95% CI	p	95% CI	p	LRTChi2	P	I2
Year of publication	0.96 (0.83–0.99)	0.58	0.97 (0.91–0.99)	0.48	4.12	0.13	51
Language	0.00 (0.00–1.00)	0.99	0.98 (0.83–1.00)	0.97	9.07	0.01	78
Country	0.89 (0.73–0.96)	0.57	0.99 (0.95–1.00)	0.62	4.24	0.12	53
Types of tumor	0.95 (0.73–0.99)	0.70	0.97 (0.86–0.99)	0.80	0.43	0.81	0
Types of tissue for detection	0.95 (0.81–0.99)	0.59	0.96 (0.88–0.99)	0.48	2.59	0.27	23
Types of ALK mutations	0.99 (0.91–1.00)	0.07	0.97 (0.77–1.00)	0.72	6.05	0.05	67
Types of material for FISH	0.90 (0.56–0.99)	0.81	0.94 (0.78–0.99)	0.26	1.83	0.40	0
Cells counted for FISH	0.92 (0.80–0.97)	0.88	0.98 (0.95–0.99)	0.99	0.25	0.88	0
Positive cutoff for FISH	0.85 (0.61–0.96)	0.34	0.99 (0.95–1.00)	0.05	4.36	0.11	54
FISH signal distance	0.92 (0.78–0.97)	0.89	0.97 (0.93–0.99)	0.72	0.61	0.74	0
Suppliers of FISH kit	0.86 (0.69–0.94)	0.37	0.97 (0.93–0.99)	0.69	3.79	0.15	47
Types of material for PCR	0.91 (0.73–0.97)	0.79	0.98 (0.93–0.99)	0.98	0.23	0.89	0
Types of PCR	0.20 (0.01–0.87)	0.03	0.69 (0.09–0.98)	0.06	6.74	0.03	70
Suppliers of ALK rearrangement Gene Diagnostic kit	0.81(0.40–0.96)	0.33	0.98 (0.91–11.00)	0.74	2.04	0.36	2
Suppliers of RNA extracted kit	0.90 (0.75–0.96)	0.64	0.98 (0.94–0.99)	0.98	1.23	0.54	0
Principle of PCR	0.98 (0.78–1.00)	0.37	0.97 (0.87–0.99)	0.78	2.00	0.37	0

FISH, fluorescence in situ hybridization; ALK, anaplastic lymphoma kinase; PCR, reverse transcriptase polymerase chain reaction.