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Novel hypothesis by which exercise improves endothelial function in CKD. Impairments in L-arginine uptake are largely mediated by activation of PKCα resulting in decreased CAT-1 transport activity and internalization of CAT-1 to the cytosol. Exercise improves L-arginine transport activity in part by decreasing PKCα expression and preventing the decline in CAT-1 activity and/or membrane localization.
