Table 2.

Cross-Validated Diagnostic Performance by Analysis Method and Fibrosis Outcomes

	Center 1 Manual Analysis	Center 2 Manual Analysis	Automated Analysis
	Any Fibrosis (Stage 0 vs Stages 1–4)
Cut-off	2.77	2.69	2.78
Sensitivity	44.4% (27.9 – 61.9)	47.2% (30.4 – 64.5)	44.4% (27.9 – 61.9)
Specificity	90.7% (79.7 – 96.9)	88.9% (77.4 – 95.8)	90.7% (79.7 – 96.9)
PPV	76.2% (52.8 – 91.8)	73.9% (51.6 – 89.8)	76.2% (52.8 – 91.8)
NPV	71.0% (58.8 – 81.3)	71.6% (59.3 – 82.0)	71.0% (58.8 – 81.3)
Total Accuracy	72.2% (61.8 – 81.1)	72.2% (61.8 – 81.1)	72.2% (61.8 – 81.1)
	Advanced Fibrosis (Stages 0–2 vs Stages 3–4)
Cut-off	3.05	3.03	3.33
Sensitivity	50.0% (11.8 – 88.2)	33.3% (4.3 – 77.7)	33.3% (4.3 – 77.7)
Specificity	91.7% (83.6 – 96.6)	94.0% (86.7 – 98.0)	90.5% (82.1 – 95.8)
PPV	30.0% (6.7 – 65.2)	28.6% (3.7 – 71.0)	20.0% (2.5 – 55.6)
NPV	96.2% (89.4 – 99.2)	95.2% (88.1 – 98.7)	95.0% (87.7 – 98.6)
Total Accuracy	88.9% (80.5 – 94.5)	90.0% (81.9 – 95.3)	86.7% (77.9 – 92.9)