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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Hepatol. 2017 Jun 22;67(5):1018–1025. doi: 10.1016/j.jhep.2017.06.014

Fig. 2. MIF-deficiency in non-myeloid cells protected mice from chronic ethanol-induced hepatic injury, inflammation and steatosis.

Fig. 2

WT→WT, Mif−/−→WT and WT→Mif −/− chimeric mice were allowed free access to diets with increasing concentrations of ethanol or pair-fed a control diet for 25 days. Enzyme activities of (A) ALT and (B) AST were measured in plasma. (C) Hepatic triglyceride content was measured in whole liver homogenates. Values with different alphabetical superscripts were significantly different from each other (p< 0.05). (D) Paraffin-embedded liver sections were stained with hematoxylin and eosin and (E) Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was quantified using ImagePro. All images were acquired using a 10X objective. Values represent means ± SEM, n = 4 pair-fed and n = 6 ethanol-fed.