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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Am J Med Genet A. 2017 Sep 26;173(11):2973–2984. doi: 10.1002/ajmg.a.38472

Table V.

NTD GG allele frequency of previously published studies by FA fortification policy in each country of origin at the time of enrollment.

Author (year) Country of origin FA fortification policy at time of enrollment NTD GG allele frequency Studies by FA fortification policy p-value
De Marco et al. (2003) Italy Voluntary* 0.32 (46/144) 0.301 (185/614)

Relton et al. (2004) United Kingdom Voluntary* 0.33 (67/206)

O’Leary (2006) Ireland Voluntary* 0.27 (72/264)

0.0468
Shaw et al. (2002) United States No fortification 0.28 (37/132) 0.365 (119/326)

Pei et al. (2014) China No fortification 0.45 (44/98)

Findley et al. (2017) United States No fortification 0.40 (38/96)

From Ren A, 2015.